ClinicalKey Latest Issue: Heart, Lung and Circulation https://www.clinicalkey.com/dura/browse/journalIssue/14439506 Content from the latest issue of Heart, Lung and Circulation. Coagulopathy in Cardiac Surgery: A Scoping Review of Prothrombin Complex Concentrate https://www.clinicalkey.com/playContent/1-s2.0-S1443950626001903 Heart, Lung and Circulation, Volume 35, Issue 9, 2026 Sep, Pages 1214-1223 | Vander Zwaag, Stanislaw, MD, DESAIC; Kukel, Imre, MD; Fassl, Jens, MD, PhD, FASE<br/>BackgroundCoagulopathy after cardiopulmonary bypass substantially contributes to postoperative bleeding, transfusion requirements, morbidity, and mortality. The traditional treatment option is fresh frozen plasma (FFP), but prothrombin complex con... https://www.clinicalkey.com/playContent/1-s2.0-S1443950626001903 Perspectives on Advance Care Planning in Adult Congenital Heart Disease: An Australian Sample https://www.clinicalkey.com/playContent/1-s2.0-S144395062600096X Heart, Lung and Circulation, Volume 35, Issue 9, 2026 Sep, Pages 1357-1365 | Wijayarathne, Pasangi Madhuka, MD; Menahem, Samuel, MD, DMedHSc<br/>IntroductionPatients with adult congenital heart disease (ACHD) now survive well into adulthood though their overall long-term survival remains below the general population. Advance care planning (ACP) has been endorsed by clinical guidelines, yet... https://www.clinicalkey.com/playContent/1-s2.0-S144395062600096X Quantification of Sarcopenia using Chest Computed Tomography of the Pectoralis Major Muscle as a Prognostic Tool for Cardiac Surgery Outcomes https://www.clinicalkey.com/playContent/1-s2.0-S1443950626000971 Heart, Lung and Circulation, Volume 35, Issue 9, 2026 Sep, Pages 1321-1330 | Nezafati, Pouya, MD; Saxena, Pankaj, MD, PhD, FRACS; Raman, Jai, MD, PhD, FRACS;...<br/>Background and AimCardiac surgery is increasingly performed on elderly, frail patients, making objective frailty markers critical for predicting outcomes. Sarcopenia, as defined by the progressive loss of muscle mass and strength, is linked to poo... https://www.clinicalkey.com/playContent/1-s2.0-S1443950626000971 Early Clinical Outcome of Perceval Aortic Valve Implantation in Townsville, Australia https://www.clinicalkey.com/playContent/1-s2.0-S1443950626000995 Heart, Lung and Circulation, Volume 35, Issue 9, 2026 Sep, Pages 1331-1336 | Nezafati, Pouya, MD; Gunasagaran, Lalita, MBBS; Yadav, Sumit, FRACS<br/>Background & AimSutureless aortic valve replacement (AVR) using the Perceval valve has emerged as a valuable alternative to conventional surgical valves, offering procedural and recovery advantages. This study presents 30-day clinical outcomes fro... https://www.clinicalkey.com/playContent/1-s2.0-S1443950626000995 Streamlining Transcatheter Aortic Valve Implantation: Lessons From Minimalist Pathways and Heart-Team Reform https://www.clinicalkey.com/playContent/1-s2.0-S1443950626001009 Heart, Lung and Circulation, Volume 35, Issue 9, 2026 Sep, Pages e129-e130 | Shah, Ashish H., MD, MD-Research, FRCP(UK)<br/>Aortic stenosis (AS) is by far the most common valvular disease in ageing populations. Over the past decade, transcatheter aortic valve implantation (TAVI) has become standard of care not only for high-surgical-risk patients but also for intermedi... https://www.clinicalkey.com/playContent/1-s2.0-S1443950626001009 Cryptogenic Young Stroke Associated With Bilateral Pulmonary Arteriovenous Malformations https://www.clinicalkey.com/playContent/1-s2.0-S1443950626001022 Heart, Lung and Circulation, Volume 35, Issue 9, 2026 Sep, Pages e120-e122 | Yenduri, Naimisha, MD, DM; Ahamed, Hisham, MD, DM; Nambiar, Vivek, MD, DM;...<br/>In 2025 a 37-year-old female presented to our hospital for evaluation of a prior cryptogenic stroke diagnosed elsewhere in 2019, when she had developed severe headache and left upper limb numbness. The aetiology of stroke was not established at th... https://www.clinicalkey.com/playContent/1-s2.0-S1443950626001022 Incidental Septal Lipoma in a Patient Evaluated for PFO Closure: What is the Best Approach? https://www.clinicalkey.com/playContent/1-s2.0-S1443950626001010 Heart, Lung and Circulation, Volume 35, Issue 9, 2026 Sep, Pages e123-e124 | Raghavan, Arjun Athreya, MD; Foyle, Ryan, MD; Kass, Malek, MD;...<br/>A 59-year-old man with hypertension and a cryptogenic transient ischaemic attack (TIA) was referred for percutaneous patent foramen ovale (PFO) closure after a positive bubble study and identification of an interatrial septal aneurysm on transthor... https://www.clinicalkey.com/playContent/1-s2.0-S1443950626001010 Implementation of Evidence-Based, Person-Centered Alternative Delivery Models for Cardiac Rehabilitation in a Rural and Remote Population: The Country Heart Attack Prevention (CHAP) Project https://www.clinicalkey.com/playContent/1-s2.0-S1443950626001034 Heart, Lung and Circulation, Volume 35, Issue 9, 2026 Sep, Pages 1337-1347 | Beleigoli, Alline, MD, PhD; Pinero de Plaza, Maria Alejandra, PhD; Gebremichael, Lemlem G., PhD;...<br/>Background & AimsAccess and adherence to cardiac rehabilitation (CR) remain suboptimal, particularly in rural and remote settings. This study evaluated the implementation of person-centred, evidence-based CR delivery model tailored to improve acce... https://www.clinicalkey.com/playContent/1-s2.0-S1443950626001034 Beyond Acute Coronary Occlusion—The Malignant STEMI Mimic https://www.clinicalkey.com/playContent/1-s2.0-S144395062600106X Heart, Lung and Circulation, Volume 35, Issue 9, 2026 Sep, Pages e125-e127 | Upadhyay, Jeet, MD; Khanna, Shaun, MBBS, MMed; Bhat, Aditya, MBBS, MPH, DDU;...<br/>ST-elevation myocardial infarction (STEMI) necessitates prompt coronary reperfusion, but conditions can mimic these electrocardiographic (ECG) changes and complicate the diagnosis. Cardiac tumours, predominantly metastatic in nature, are rare and ... https://www.clinicalkey.com/playContent/1-s2.0-S144395062600106X Cost-Effectiveness of Impella Versus Veno-Arterial Extracorporeal Membrane Oxygenation in Patients With Acute Myocardial Infarction Cardiogenic Shock https://www.clinicalkey.com/playContent/1-s2.0-S1443950626001915 Heart, Lung and Circulation, Volume 35, Issue 9, 2026 Sep, Pages 1313-1320 | Batchelor, Riley, FRACP; Ball, Jocasta, PhD; Theng, Steven, PhD;...<br/>BackgroundRecent trial data support the use of the Impella heart pump for the management of patients with cardiogenic shock (CS). However, questions regarding the cost-effectiveness of Impella compared with alternative mechanical circulatory suppo... https://www.clinicalkey.com/playContent/1-s2.0-S1443950626001915 Outcomes of TAVR Plus TEVAR Versus TAVR Alone in Patients with Concomitant Aortic Stenosis and Thoracic Aortic Aneurysm https://www.clinicalkey.com/playContent/1-s2.0-S144395062600185X Heart, Lung and Circulation, Volume 35, Issue 9, 2026 Sep, Pages e115-e119 | Agrawal, Ankit, MD; Banga, Akshat, MBBS, MD; Bhagat, Umesh, MD;...<br/>Baseline patient characteristics. Variable / Outcome TAVR, n=5,220 (%) TAVR+TEVAR, n=77 (%) p-value Female 1,496 (28.7%) 29 (37.9%) 0.220 Age, years 0.238 18–44 39 (0.8%) 6 2,236 (42.9%) 44 (57.6%) Coronary artery disease 3,529 (67.6%) 51 (66.4%) ... https://www.clinicalkey.com/playContent/1-s2.0-S144395062600185X Does a Digital Prehabilitation Solution Informed by Evidence-Based Interventions Reduce the Healthcare Burden and Improve Outcomes for Patients Awaiting Cardiac Surgery?—A Systematic Review https://www.clinicalkey.com/playContent/1-s2.0-S1443950626002234 Heart, Lung and Circulation, Volume 35, Issue 9, 2026 Sep, Pages 1224-1244 | Hines, Claire, MPhysio; Farragher, Joshua, PhD; Vlahos, Ross, PhD;...<br/>Background and AimsPrehabilitation before cardiac surgery targets modifiable risk factors to enhance surgical readiness and recovery. It can reduce complications, mortality, and hospital stay; however, remains underused in routine cardiac care. As... https://www.clinicalkey.com/playContent/1-s2.0-S1443950626002234 Outcomes Selected by Pressure Wire in Coronary Artery Revascularisation: The OSCAR Study https://www.clinicalkey.com/playContent/1-s2.0-S1443950626001940 Heart, Lung and Circulation, Volume 35, Issue 9, 2026 Sep, Pages 1280-1287 | Chia, Justin, BMed, MMed(ClinEpi); Rea, Elisabeth Balarezo, BMus; Pathan, Faraz, MBBS;...<br/>BackgroundPressure wire-derived indices are widely used to guide revascularisation of angiographically intermediate coronary lesions. While fractional flow reserve (FFR) remains the reference standard, the resting full-cycle ratio (RFR) and other ... https://www.clinicalkey.com/playContent/1-s2.0-S1443950626001940 Low Albumin and Elevated FIB-4 Are Associated With Adverse Outcomes After the Fontan Procedure https://www.clinicalkey.com/playContent/1-s2.0-S1443950626001058 Heart, Lung and Circulation, Volume 35, Issue 9, 2026 Sep, Pages 1348-1356 | Jarasvaraparn, Chaowapong, MD; Perkins, Anthony J.; Rodenbarger, Andrew, MD;...<br/>BackgroundFontan-associated liver disease contributes to long-term morbidity and mortality. This study evaluated whether non-invasive liver fibrosis scores—aspartate transaminase to platelet ratio index (APRI) and fibrosis-4 (FIB-4) and routine cl... https://www.clinicalkey.com/playContent/1-s2.0-S1443950626001058 Overlap Between Heart Failure and Menopause: Diagnostic Challenges and Clinical Implications https://www.clinicalkey.com/playContent/1-s2.0-S1443950626004178 Heart, Lung and Circulation, Volume 35, Issue 9, 2026 Sep, Pages 1203-1213 | Kwan, Timothy Nathan, MD; Yan, Aimy, MD; Jain, Pankaj, MBBS, PhD;...<br/>Heart failure and menopause commonly coexist in middle-aged women, but overlapping symptomatology often complicates diagnosis. Moreover, physiological changes during menopause and normal ageing can predispose patients to cardiac symptoms and cardi... https://www.clinicalkey.com/playContent/1-s2.0-S1443950626004178 Diabetes and Risk of Radial Artery Occlusion After Distal Radial Access: Insights From the KODRA Registry https://www.clinicalkey.com/playContent/1-s2.0-S1443950626001885 Heart, Lung and Circulation, Volume 35, Issue 9, 2026 Sep, Pages 1288-1297 | Kim, Byung Gyu, MD; Cho, Hyun, MD; Kim, Sung Eun, MD;...<br/>BackgroundDistal radial access (DRA) is increasingly used for coronary angiography (CAG) and percutaneous coronary intervention, but evidence in patients with diabetes is limited. We investigated whether diabetes is associated with forearm radial ... https://www.clinicalkey.com/playContent/1-s2.0-S1443950626001885 Letter to the Editor regarding: “Attainment of Low-Density Lipoprotein Cholesterol Goals and Statin Use in Patients With Atherosclerotic Cardiovascular Disease in Australian General Practice: Are We Doing Enough?” https://www.clinicalkey.com/playContent/1-s2.0-S1443950626000636 Heart, Lung and Circulation, Volume 35, Issue 9, 2026 Sep, Pages e128-e128 | Dimmitt, Simon B., BMedSc, MBBS, FRACP, FCSANZ; Stampfer, Hans G., MBBS, FRANZCP; Kennedy, Michael C., MBBS, MD, FRACP;...<br/>The useful analysis by Audhem et al. [ 1] demonstrates falling statin compliance over time, less on lower statin dosages. Adverse effects (AEs), usually dose-related [ 2], were noted in Audhem et al. [ 1] and other studies [ 3,4] and appear a sign... https://www.clinicalkey.com/playContent/1-s2.0-S1443950626000636 Editorial Board https://www.clinicalkey.com/playContent/1-s2.0-S1443950626017087 Heart, Lung and Circulation, Volume 35, Issue 9, 2026 Sep, Pages iii-iv<br/>(no summary available) https://www.clinicalkey.com/playContent/1-s2.0-S1443950626017087 Nature and Heart Health: Conversations With Your Patients https://www.clinicalkey.com/playContent/1-s2.0-S1443950626016951 Heart, Lung and Circulation, Volume 35, Issue 9, 2026 Sep, Pages 1366-1366<br/>Nature and Heart Health: Conversations With Your Patients Victoria Leitch, BSci(Biomed), MScC, PhD Anna Gurnhill BA(Hons) Time in Nature as a Preventive Health Strategy Spending time in nature is an effective, affordable primary and secondary heal... https://www.clinicalkey.com/playContent/1-s2.0-S1443950626016951 The Lp(a) Revolution in Dyslipidaemia Management, From Obscurity to Class 1 Recommendation: Aligning Australian Practice With Global Guidelines https://www.clinicalkey.com/playContent/1-s2.0-S144395062601694X Heart, Lung and Circulation, Volume 35, Issue 9, 2026 Sep, Pages 1187-1189 | Hare, David L., OAM, DPM, FRACP<br/>The May 2026 issue of Heart Lung, and Circulation included two articles examining the prevalence of lipoprotein(a) [Lp(a)] testing in two Australian populations [ 1, 2]. Eccleston et al. [ 1] in a retrospective study of over 1 million medical reco... https://www.clinicalkey.com/playContent/1-s2.0-S144395062601694X Initial 4-Year Experience With Microaxial Flow Pumps Within a Tertiary Centre in Regional Australia https://www.clinicalkey.com/playContent/1-s2.0-S1443950626001988 Heart, Lung and Circulation, Volume 35, Issue 9, 2026 Sep, Pages 1306-1312 | Quirk, Thomas, BMed; Sritharan, Shanathan, BMed, MPH/MHLM; Short, Kaylea, BNurs;...<br/>Background & AimThe Microaxial Flow Pump (MFP) is a miniaturised rotary pump that aspirates blood from the left ventricle and expels it into the ascending aorta. It unloads the left ventricle and increases mean arterial pressure and cardiac output... https://www.clinicalkey.com/playContent/1-s2.0-S1443950626001988 Smartwatch-Based Heart Rate Detection in Atrial, Ventricular and Pulseless Arrhythmias https://www.clinicalkey.com/playContent/1-s2.0-S1443950626001976 Heart, Lung and Circulation, Volume 35, Issue 9, 2026 Sep, Pages 1298-1305 | Turnbull, Samual, BSc; Gupta, Anunay, MD, DM; Garikapati, Kartheek, MBBS;...<br/>Background & AimSmartwatches can provide a non-invasive heart rate (HR) monitoring to aid screening for atrial fibrillation, however, the accuracy of HR detections in the context of other arrhythmias requires further investigation. We aimed to ass... https://www.clinicalkey.com/playContent/1-s2.0-S1443950626001976 Meta-Analysis of Randomised Controlled Trials on the Efficacy of Direct Oral Anticoagulants in Left Ventricular Thrombosis: An Updated Perspective https://www.clinicalkey.com/playContent/1-s2.0-S1443950626002222 Heart, Lung and Circulation, Volume 35, Issue 9, 2026 Sep, Pages 1259-1270 | Resende, Bernardo, MD; Simões, Mariana, MD; Ferraz-Costa, Gonçalo, MD, MSc;...<br/>BackgroundLeft ventricular thrombus (LVT) is associated with significant morbidity and mortality. Current guidelines recommend direct oral anticoagulants (DOACs) and vitamin K antagonists for LVT treatment, although these recommendations are based... https://www.clinicalkey.com/playContent/1-s2.0-S1443950626002222 Haemodynamically Threatened Pulmonary Embolism (PE-HT): A Proposed Sub-Classification for Regional ICUs https://www.clinicalkey.com/playContent/1-s2.0-S1443950626001873 Heart, Lung and Circulation, Volume 35, Issue 9, 2026 Sep, Pages e131-e132 | Maan, Prashant, MBBS, MD, EDIC, FCICM<br/>Intermediate–high risk pulmonary embolism (PE) represents a persistent therapeutic and diagnostic challenge in acute care. Although current frameworks such as the ESC (European Society of Cardiology) [ 1] and CHEST (American College of Chest Physi... https://www.clinicalkey.com/playContent/1-s2.0-S1443950626001873 Heart Failure in Menopause: An Emerging Cardiovascular Challenge https://www.clinicalkey.com/playContent/1-s2.0-S1443950626004099 Heart, Lung and Circulation, Volume 35, Issue 9, 2026 Sep, Pages 1190-1192 | Khanna, Shaun, MBBS, MMed, FRACP; Arnott, Clare, MBBS, PhD, FRACP<br/>Menopause has traditionally been conceptualised as a reproductive milestone characterised by cessation of ovarian function and often accompanied by the emergence of vasomotor and systemic symptoms [ 1]. Increasingly, however, it is being recognise... https://www.clinicalkey.com/playContent/1-s2.0-S1443950626004099 ROBITAL Technique: Combination of Sequential ROtational and orBITAL Atherectomy in Management of Complex Coronary Calcium https://www.clinicalkey.com/playContent/1-s2.0-S1443950626000892 Heart, Lung and Circulation, Volume 35, Issue 9, 2026 Sep, Pages 1271-1279 | Aria, Soleiman, MBBS, MA(CANTAB), MSc; Hlaing, Su Hnin, MBBS, MMed, FRACP; Walters, Darren L., MBBS, MPhil, FRACP;...<br/>Background & AimsHeavily calcified coronary artery disease remains one of the most formidable challenges in contemporary percutaneous coronary interventions, often leading to suboptimal stent expansion, procedural complications, and poor long-term... https://www.clinicalkey.com/playContent/1-s2.0-S1443950626000892 Health Care Workers’ Preferences in the Delivery of Atrial Fibrillation Screening: A Systematic Review https://www.clinicalkey.com/playContent/1-s2.0-S1443950626001897 Heart, Lung and Circulation, Volume 35, Issue 9, 2026 Sep, Pages 1245-1258 | Halahakone, Ureni, MHM, MD; Borg, Samantha J., BHSC(Nut&Diet); Senanayake, Sameera, MSc, PhD;...<br/>BackgroundHealth care workers (HCWs) play a crucial role in the success of atrial fibrillation (AF) screening programs. However, screening for AF remains underused due to organisational barriers, such as time constraints, user knowledge of the int... https://www.clinicalkey.com/playContent/1-s2.0-S1443950626001897 Cardiovascular Drug Access in Australia and New Zealand: New PBS and PHARMAC Listings, 2023–2025 https://www.clinicalkey.com/playContent/1-s2.0-S1443950626004063 Heart, Lung and Circulation, Volume 35, Issue 9, 2026 Sep, Pages 1193-1202 | Ciofani, Jonathan L., MPH, MD; Puranik, Rajesh, MBBS, PhD; Ekmejian, Avedis, MBBS, PhD;...<br/>BackgroundCardiovascular disease is a leading cause of death in Australia and New Zealand. Publicly subsidised access to new cardiovascular medications is governed by the PBS (Pharmaceutical Benefits Scheme) in Australia and PHARMAC (Pharmaceutica... https://www.clinicalkey.com/playContent/1-s2.0-S1443950626004063