ClinicalKey Latest Issue: Heart, Lung and Circulation https://www.clinicalkey.com/dura/browse/journalIssue/14439506 Content from the latest issue of Heart, Lung and Circulation. Initiators of Semaglutide in General Practice in New South Wales, 2020–2023: A Retrospective Cohort Study https://www.clinicalkey.com/playContent/1-s2.0-S1443950625016907 Heart, Lung and Circulation, Volume 35, Issue 4, 2026 Apr, Pages 554-562 | Kuo, Nicholas I-Hsien, PhD; Hill, Flynn, PhD; Arnott, Clare, PhD;...<br/>AimWe aimed to analyse trends and demographic and clinical profiles in initial prescriptions of semaglutide (“Ozempic”) by general practitioners in New South Wales between 2020 and 2023. MethodThis retrospective cohort study used electronic medica... https://www.clinicalkey.com/playContent/1-s2.0-S1443950625016907 Mechanical Tricuspid Valve Thrombosis: The Role of Multimodality Diagnostic Imaging https://www.clinicalkey.com/playContent/1-s2.0-S1443950625017482 Heart, Lung and Circulation, Volume 35, Issue 4, 2026 Apr, Pages e52-e54 | King, Ryan E., MD, MPH; Teng, Lung En, MBBS; Zentner, Dominica, MBBS, FRACP, PhD<br/>A 25-year-old female was brought into the Emergency Department with acute onset left sided pleuritic chest pain and exertional dyspnoea. The patient had a history of congenital heart disease: hypoplastic right ventricle (RV), RV outflow tract obst... https://www.clinicalkey.com/playContent/1-s2.0-S1443950625017482 Cardiac Society of Australia and New Zealand https://www.clinicalkey.com/playContent/1-s2.0-S1443950626001265 Heart, Lung and Circulation, Volume 35, Issue 4, 2026 Apr, Pages 590-591<br/>(no summary available) https://www.clinicalkey.com/playContent/1-s2.0-S1443950626001265 Factors Affecting Volume Load Management in Patients With Heart Failure: A Path Analysis Using a Multimediation Model https://www.clinicalkey.com/playContent/1-s2.0-S1443950625016981 Heart, Lung and Circulation, Volume 35, Issue 4, 2026 Apr, Pages 475-485 | Wu, Qiuping, MN; Pei, Haoyu, BN; Zhang, Limin, BN;...<br/>BackgroundEffective management of volume overload is essential for improving the prognosis of heart failure (HF), which is often complicated by exacerbations and rehospitalisations. Psychosocial and behavioural factors significantly influence volu... https://www.clinicalkey.com/playContent/1-s2.0-S1443950625016981 Predictors of Obstructive Coronary Artery Disease in Positive Electrocardiogram, Negative Echocardiogram Stress Tests: A Single-Centre Retrospective Analysis https://www.clinicalkey.com/playContent/1-s2.0-S1443950625017457 Heart, Lung and Circulation, Volume 35, Issue 4, 2026 Apr, Pages 486-491 | Dind, Andrew, MBBS; McGhie, Daniel, MBBS; McIntyre, Daniel, MBBS, PhD;...<br/>AimIn exercise stress testing (EST), a discordant result with electrocardiogram (ECG)-positive and transthoracic echocardiogram (TTE)-negative is commonly encountered. This study aimed to determine the predictors of obstructive coronary artery dis... https://www.clinicalkey.com/playContent/1-s2.0-S1443950625017457 Destination Ventricular Assist Device: A Single-Centre Experience With a Newly Approved Therapy for Advanced Heart Failure https://www.clinicalkey.com/playContent/1-s2.0-S144395062501697X Heart, Lung and Circulation, Volume 35, Issue 4, 2026 Apr, Pages 468-474 | Rubinstein, Matanyahu, MD; Lim, Steven, MBBS; McLean, Janelle, BSN, GradDipICU;...<br/>Background & AimsDestination ventricular assist device (VAD) is a newly approved upfront therapy for advanced heart failure in Australia, presenting a therapeutic option for patients who are unsuitable candidates for cardiac transplantation. This ... https://www.clinicalkey.com/playContent/1-s2.0-S144395062501697X Impact on Transport Resource Utilisation in Newborn Congenital Heart Disease Diagnosed Postnatally https://www.clinicalkey.com/playContent/1-s2.0-S1443950625017032 Heart, Lung and Circulation, Volume 35, Issue 4, 2026 Apr, Pages 529-537 | Jeston, Sally E., NP, MN; Hickey, Leah M., MB BCh, MD; Zannino, Diana, MSc;...<br/>AimThis study aimed to describe and compare neonatal retrieval medical interventions among newborns with a postnatal vs antenatal diagnosis of critical congenital heart disease (CHD). MethodThe study design was a retrospective medical record revie... https://www.clinicalkey.com/playContent/1-s2.0-S1443950625017032 Trends Between Socioeconomic Status and Hospitalisation Outcomes in Patients With Rheumatic Valve Disease: A United States Population-Based Study https://www.clinicalkey.com/playContent/1-s2.0-S1443950625017615 Heart, Lung and Circulation, Volume 35, Issue 4, 2026 Apr, Pages e47-e49 | Abdallah, Nadhem, MD; Alsayed, Momen, MBBS<br/>Baseline characteristics of patients hospitalised with rheumatic valve disease, stratified by income status. Characteristic High income Low income p-value Sex Male (%) 44.5 41.1 https://www.clinicalkey.com/playContent/1-s2.0-S1443950625017615 Impact of Dedicated Cardiologist Input on the Rate of Prescription of Guideline-Directed Medical Therapy After Coronary Artery Bypass Graft Surgery—A Retrospective Cohort Study (The ROSS Effect) https://www.clinicalkey.com/playContent/1-s2.0-S1443950625017354 Heart, Lung and Circulation, Volume 35, Issue 4, 2026 Apr, Pages e43-e46 | Lim, Matthew Y., MBBS; Nguyen, Mau T., MBBS, MBiostat; Winton, Tyler, MD;...<br/>Introduction The implementation of a multidisciplinary team has long been a guideline-recommended model of care for patients undergoing coronary artery bypass graft (CABG) surgery [ 1–3]. Despite this, most cardiothoracic surgery units (CTSUs) in ... https://www.clinicalkey.com/playContent/1-s2.0-S1443950625017354 Corrigendum to: Abstract 727, Vol 34, Supplement 4, Page S567 (2025) (Abstracts for the 73rd Annual Scientific Meeting of the Cardiac Society of Australia and New Zealand, 14–17 August 2025) entitled ”Iron Deficiency in Symptomatic Atrial Fibrillation: A Multi-Centre Prospective Observational Study” https://www.clinicalkey.com/playContent/1-s2.0-S1443950626001095 Heart, Lung and Circulation, Volume 35, Issue 4, 2026 Apr, Pages e65-e65 | Watson, A.; Ferreira, D.; Chee, A.;...<br/>The name of the first author A. Watson is incorrect and should read A. Wilson. We apologise for any inconvenience. https://www.clinicalkey.com/playContent/1-s2.0-S1443950626001095 ANZSCTS ASM advert https://www.clinicalkey.com/playContent/1-s2.0-S1443950626001824 Heart, Lung and Circulation, Volume 35, Issue 4, 2026 Apr, Pages 588-589<br/>(no summary available) https://www.clinicalkey.com/playContent/1-s2.0-S1443950626001824 A Scoping Review of Australian Hospitals’ Policies on the Deactivation of Implantable Cardioverter Defibrillators https://www.clinicalkey.com/playContent/1-s2.0-S1443950626000351 Heart, Lung and Circulation, Volume 35, Issue 4, 2026 Apr, Pages 451-459 | Grose, Daniel, MD; Corbett, Cathy, MBChB; Walker, Anne, MBBS;...<br/>AimMore older adults are living with an implantable cardioverter defibrillator (ICD). Deactivation rates for those approaching end-of-life are low, risking undue distress and an undignified death. This scoping review aimed to determine the availab... https://www.clinicalkey.com/playContent/1-s2.0-S1443950626000351 From PLATO to Practice: The Challenge of Translating Trial Evidence https://www.clinicalkey.com/playContent/1-s2.0-S1443950625017494 Heart, Lung and Circulation, Volume 35, Issue 4, 2026 Apr, Pages e61-e62 | Shah, Ashish H., MD, MD-Research, FRCP<br/>The PLATO (Study of Platelet Inhibition and Patient Outcomes) trial [ 1], published in 2009, represented a landmark in the management of acute coronary syndromes (ACS). Enrolling more than 18,000 patients, it reported that ticagrelor reduced vascu... https://www.clinicalkey.com/playContent/1-s2.0-S1443950625017494 Editorial Board https://www.clinicalkey.com/playContent/1-s2.0-S1443950626001241 Heart, Lung and Circulation, Volume 35, Issue 4, 2026 Apr, Pages iii-iv<br/>(no summary available) https://www.clinicalkey.com/playContent/1-s2.0-S1443950626001241 Radial Artery Graft Following Transradial Catheterisation: Efficacy of Preoperative Ultrasound Screening https://www.clinicalkey.com/playContent/1-s2.0-S1443950625016920 Heart, Lung and Circulation, Volume 35, Issue 4, 2026 Apr, Pages 460-467 | Otsuka, Ryohei, MD; Saito, Shunei, MD, PhD; Nakahata, Kazuhiko;...<br/>BackgroundAlthough the radial artery (RA) has long been the primary entry site for coronary angiography or intervention, there have been few studies on the viability of using cannulated radial arteries as a graft. Several studies have found that r... https://www.clinicalkey.com/playContent/1-s2.0-S1443950625016920 LeAAPing Up From Down Under: Australia and Aotearoa New Zealand’s Participation in the LeAAPS Trial https://www.clinicalkey.com/playContent/1-s2.0-S1443950625017470 Heart, Lung and Circulation, Volume 35, Issue 4, 2026 Apr, Pages e59-e60 | DeBoard, Zach M., MD FACS<br/>The left atrial appendage exclusion for prophylactic stroke reduction (LeAAPS) trial has concluded enrolment and intervention. This prospective, randomised controlled study included adult cardiac surgery patients without, but at risk for, atrial f... https://www.clinicalkey.com/playContent/1-s2.0-S1443950625017470 A Hidden Preload Contributor: Silent Renal Arteriovenous Fistula in Severe Aortic Stenosis https://www.clinicalkey.com/playContent/1-s2.0-S1443950625017512 Heart, Lung and Circulation, Volume 35, Issue 4, 2026 Apr, Pages e50-e51 | Omote, Kazunori, MD, PhD, FACC, FESC; Terada, Rikumu, RT; Kudo, Tamaki, RT;...<br/>An 86-year-old woman was referred for treatment of heart failure with aortic stenosis (AS). Transthoracic echocardiography demonstrated a peak aortic valve velocity of 4.1 m/s. The aortic valve area was calculated as 0.92 cm 2 using the continuity... https://www.clinicalkey.com/playContent/1-s2.0-S1443950625017512 Beyond Blood Pressure: Peripheral Artery Disease Diagnosis With the Ankle-Brachial Humidity Index https://www.clinicalkey.com/playContent/1-s2.0-S1443950625017056 Heart, Lung and Circulation, Volume 35, Issue 4, 2026 Apr, Pages 547-553 | Adar, Adem, MD; Akbay, Ertan, MD; Cakan, Fahri, MD;...<br/>BackgroundThe ankle-brachial index (ABI) is the standard non-invasive diagnostic tool for peripheral artery disease, but it has some limitations, particularly in patients with arterial calcification. This study introduces the ankle-brachial humidi... https://www.clinicalkey.com/playContent/1-s2.0-S1443950625017056 Effects of Transradial Catheterisation on Radial Artery Bypass Graft Patency: A Systematic Review and Meta-Analysis https://www.clinicalkey.com/playContent/1-s2.0-S1443950625017597 Heart, Lung and Circulation, Volume 35, Issue 4, 2026 Apr, Pages 444-450 | Wang, Yantong, BMedSc; Sharma, Varun, MBBS, PhD; Vu, Tony, MD;...<br/>BackgroundTransradial catheterisation is the default approach of coronary angiography, and the radial artery (RA) is a popular conduit choice for coronary artery bypass grafting (CABG). Whether a previously catheterised RA (CRA) remains an optimal... https://www.clinicalkey.com/playContent/1-s2.0-S1443950625017597 National Funding for Cardiac Arrest Research in Australia: An Analysis of Competitive Grant Schemes https://www.clinicalkey.com/playContent/1-s2.0-S1443950625017561 Heart, Lung and Circulation, Volume 35, Issue 4, 2026 Apr, Pages 492-502 | Pointon, Samuel, MD; Ingles, Jodie, PhD, MPH; Timbs, Sue, BCom, LLB;...<br/>BackgroundSudden cardiac arrest (SCA) affects 26,000 Australians each year, with an approximately 90% fatality rate. MethodData from 2013 to 2023, inclusive for National Health and Medical Research Council (NHMRC) and 2020–2024 for National Heart ... https://www.clinicalkey.com/playContent/1-s2.0-S1443950625017561 Cancer Survivors’ and Health Care Professionals’ Views on Managing Cardiovascular Disease Risk in Cancer: A Qualitative Study to Inform a Model of Care https://www.clinicalkey.com/playContent/1-s2.0-S1443950625017020 Heart, Lung and Circulation, Volume 35, Issue 4, 2026 Apr, Pages 563-576 | Kemp, Emma, PhD; Lawn, Sharon, PhD; Miller, Michelle, PhD;...<br/>AimPrevention and management of cardiovascular disease (CVD) in cancer survivors is crucial to reduce the burden of comorbid CVD; however, little is known about preferred models of care to address CVD risks. This study examined Australian cancer s... https://www.clinicalkey.com/playContent/1-s2.0-S1443950625017020 Dabigatran Failure Leading to Stroke: A Cautionary Tale in Anticoagulant Switching Before AF Ablation Procedures https://www.clinicalkey.com/playContent/1-s2.0-S1443950626000363 Heart, Lung and Circulation, Volume 35, Issue 4, 2026 Apr, Pages e57-e58 | Ward, Michael R., MBBS, FRACP, PhD, FSCANZ<br/>I write to highlight a critical case that underscores important clinical considerations in anticoagulation management for patients undergoing atrial fibrillation (AF) ablation procedures. The practice of switching from Factor Xa inhibitors (e.g., ... https://www.clinicalkey.com/playContent/1-s2.0-S1443950626000363 Health-Related Quality-of-Life and its Determinants After Acute Coronary Syndrome Caused by Spontaneous Coronary Artery Dissection https://www.clinicalkey.com/playContent/1-s2.0-S1443950625017366 Heart, Lung and Circulation, Volume 35, Issue 4, 2026 Apr, Pages 538-546 | Dang, Quan M., MD; Zaheen, Mithila, MBBS; Pender, Patrick, MBBS;...<br/>BackgroundSpontaneous coronary artery dissection (SCAD) is a cause of acute coronary syndrome linked with profound impact on mental health and health-related quality-of-life (HRQoL). This study aimed to explore the determinants of HRQoL for patien... https://www.clinicalkey.com/playContent/1-s2.0-S1443950625017366 Heart Foundation Walking Launches New Digital Referral Pathway https://www.clinicalkey.com/playContent/1-s2.0-S1443950626001101 Heart, Lung and Circulation, Volume 35, Issue 4, 2026 Apr, Pages 587-587<br/>Movement as Medicine Despite the wealth of evidence demonstrating the benefits of physical activity, less than a quarter of people in Australia achieve the levels recommended by the Australian physical activity and exercise guidelines published by... https://www.clinicalkey.com/playContent/1-s2.0-S1443950626001101 Temporal Trends in Cardiovascular Health in Australians With a History of Cardiovascular Diseases https://www.clinicalkey.com/playContent/1-s2.0-S1443950625017391 Heart, Lung and Circulation, Volume 35, Issue 4, 2026 Apr, Pages 577-586 | Rehman, Sabah, MBBS, PhD; Shah, Mohammad, PhD; Gall, Seana, PhD<br/>BackgroundChanges in cardiovascular health (CVH) in people with previous cardiovascular disease (CVD), including stroke or heart disease may reflect the success of secondary prevention strategies. This has not been examined among adult Australians... https://www.clinicalkey.com/playContent/1-s2.0-S1443950625017391 Barriers and Facilitators to Implementing Guideline Recommendations for Key Aspects of Familial Hypercholesterolemia Management in Australia: Primary Care Integration, Paediatric Management, and Treatment Adherence https://www.clinicalkey.com/playContent/1-s2.0-S1443950625016919 Heart, Lung and Circulation, Volume 35, Issue 4, 2026 Apr, Pages 517-528 | Sarkies, Mitchell, PhD; Manski-Nankervis, Jo-Anne, PhD, FRACGP; Srinivasan, Shubha, PhD, FRACP;...<br/>Background & AimFamilial hypercholesterolaemia (FH) is a genetic condition that causes high plasma levels of low-density lipoprotein cholesterol, significantly increasing the risk of premature atherosclerotic cardiovascular disease. FH remains und... https://www.clinicalkey.com/playContent/1-s2.0-S1443950625016919 Pushing the Envelope in Interventional Cardiology https://www.clinicalkey.com/playContent/1-s2.0-S1443950626001071 Heart, Lung and Circulation, Volume 35, Issue 4, 2026 Apr, Pages 441-443 | Magdy, Joseph S., MD; Sarathy, Kiran S., MD; Nagaraja, Vinayak, MD<br/>T.S. Eliot’s observation that “Only those who will risk going too far can possibly find out how far one can go” eloquently captures the essence of the rapidly progressing field of interventional cardiology, a field defined by continuous innovation... https://www.clinicalkey.com/playContent/1-s2.0-S1443950626001071 TAVR in Bicuspid Aortic Valve Disease: A Meta-Analysis of Surgical Comparison and Anatomic Predictors https://www.clinicalkey.com/playContent/1-s2.0-S1443950625017573 Heart, Lung and Circulation, Volume 35, Issue 4, 2026 Apr, Pages 503-516 | Lingamsetty, Shanmukh Sai Pavan, MBBS; Thyagaturu, Harshith, MD; Jitta, Sahas Reddy, MD;...<br/>BackgroundDespite the proven efficacy of transcatheter aortic valve replacement (TAVR) in treating tricuspid aortic valve stenosis, the bicuspid aortic valve (BAV) population has been excluded from most of the landmark trials. AimThis study aimed ... https://www.clinicalkey.com/playContent/1-s2.0-S1443950625017573